LYMPHOCYTES T CIBLÉS PRÉSENTANT UNE CYTOTOXICITÉ VIS-À-VIS DE CELLULES IMMUNOSUPPRESSIVES

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专利权人:

The General Hospital Corporation

发明人:

MAUS, Marcela

申请号：

EP18738854

公开号：

EP3568466A4

申请日:

2018.01.10

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Described herein are methods for producing and utilizing T cells comprising a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain specific for a target tumor antigen, and a polypeptide comprising an extracellular antigen binding domain specific for an extracellular polypeptide expressed on an immunosuppressive cell. The technology described herein is related to methods of treating cancer, specifically solid tumors, by targeting immunosuppressive cells found within the tumor microenvironment.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/