CONSTRUCTION OF CHIMERIC ANTIGEN RECEPTOR TARGETING CD20 ANTIGEN AND ACTIVITY IDENTIFICATION OF ENGINEERED T CELLS THEREOF

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专利权人:

CELLULAR BIOMEDICINE GROUP (WUXI) LTD.;CELLULAR BIOMEDICINE GROUP (SHANGHAI) LTD.

发明人:

Yihong YAO,Jiaqi HUANG,Shigui ZHU,Wei ZHU,Xin YAO,Zhiyuan LI,Li ZHANG,Lin ZHU,Anyun MA,Yutian WEI,Yanfeng LI,Qingxia WANG,Jiaping HE

申请号：

US16484482

公开号：

US20200002400A1

申请日:

2018.02.08

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/