Kondareddiar RAMALINGAM;Ramachandran RANGANATHAN;Edmund R. MARINELLI;Rolf E. SWENSON;Radhakrishna PILLAI
发明人:
Ramachandran RANGANATHAN,Kondareddiar RAMALINGAM,Radhakrishna PILLAI,Edmund R. MARINELLI,Rolf E. SWENSON
申请号：
US13456747
公开号：
US20120258043A1
申请日:
2012.04.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLeX) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLeX compositions. In particular, the disclosed SLeX compounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLeX compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl LeX, and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.
