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INHIBITEURS DE KV1.3 ET LEUR APPLICATION MÉDICALE
专利权人:
4SC DISCOVERY GMBH
发明人:
TASLER, Stefan,KRIMMELBEIN, Ilga,KRAUS, Jürgen,ZAJA, Mirko
申请号:
EPEP2016/055451
公开号:
WO2016/146583A1
申请日:
2016.03.14
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention relates to a compound of the general formula (II) or a salt or solvate thereof, as well as medical uses involving them, wherein A1 is selected from the group consisting of N and C-R8; A2 is selected from the group consisting of N and C-R3, A3 is selected from the group consisting of N and C-R9; A4 and A5 and A6 are independently selected from the group consisting of N and C-R1; R1 is selected from the group consisting of hydrogen, (C1-C3)alkyl, halogen, (C1-C3)alkoxy, and (C1-C3)haloalkyl; R2 is selected from the group consisting of hydrogen, halogen, and (C1-C3)alkyl; R3 is selected from the group consisting of hydrogen, (C1-C3)alkyl, NR4R5, (C1-C3)alkyl- NR4R5, and cyano, wherein R4 and R5 are independently selected from the group consisting of hydrogen, (C3-C5)cycloalkyl, (C3-C5)heterocycloalkyl and (C1-C3)alkyl, or R4 and R5 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring optionally comprising in addition to the aforementioned nitrogen atom a further heteroatom group selected from the group consisting of O and NR6, wherein R6 is selected from the group consisting of hydrogen, methyl, acetyl and formyl; Y is selected from the group consisting of O and S; R8 is selected from the group consisting of (C1-C4)alkyl, (C3-C5)cycloalkyl and (C3-C5)heterocycloalkyl; and R9 is selected from the group consisting of hydrogen, (C1-C3)alkyl and (C1-C3)alkoxy; wherein certain particular compounds are excluded py proviso, and methods for producing such compounds.Cette invention concerne un composé de formule générale (II) ou un sel ou un solvate de celui-ci, ainsi que des utilisations médicales les impliquant, où A1 est choisi dans le groupe constitué par N et C-R8; A2 est choisi dans le groupe constitué par N et C-R3, A3 est choisi dans le groupe constitué par N et C-R9; A4 et A5 et A6 sont indépendamment choisis dans le groupe constitué par N et C-R1; R1est choisi dans le groupe constitué par un atome d
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