The present invention provides Orally disintegrating solid pharmaceutical preparation such as tablets, it is made and particle and the additive etc. that would indicate that active pharmaceutical ingredient control release carry out tabletting, the present invention provides the Orally disintegrating solid pharmaceutical preparation coatings of the particle comprising being coated by coatings, the coatings include to provide the polymer for the casting films that elongation when having fracture is about 100 ~ about 700%. Using the preparation, the rupture of the particle during can inhibit tabletting in the preparation of Orally disintegrating solid pharmaceutical preparation, the Orally disintegrating solid pharmaceutical preparation includes the particle that the release of active pharmaceutical ingredient is controlled.本發明提供了口腔崩解固體製劑如片劑,其通過將顯示出藥物活性成分控制釋放的微粒和添加劑等進行壓片而製得,本發明提供了包含由包衣層包衣的微粒的口腔崩解固體製劑包衣層,所述包衣層包含提供具有斷裂時的伸長率爲約100~約700%的流延膜的聚合物。利用所述製劑,在口腔崩解固體製劑的製備中可抑制壓片期間的微粒的破裂,所述口腔崩解固體製劑包含藥物活性成分的釋放得到控制的微粒。
