The present invention provides an orally-disintegrating solid preparation such as a tablet produced by tabletting fine granules showing controlled release of a pharmaceutically active ingredient and an additive, and the like, and the orally-disintegrating solid preparation containing fine granules coated with a coating layer containing a polymer affording a casting film having an elongation at break of about 100 - about 700%. With the preparation, breakage of fine granules during tabletting can be suppressed in the production of an orally-disintegrating solid preparation containing fine granules showing controlled release of a pharmaceutically active ingredient.本發明提供了口腔崩解固體製劑如片劑,其通過將顯示出藥物活性成分控制釋放的微粒和添加劑等進行壓片而製得,本發明提供了包含由包衣層包衣的微粒的口腔崩解固體製劑包衣層,所述包衣層包含提供具有斷裂時的伸長率為約100~約700%的流延膜的聚合物。利用所述製劑,在口腔崩解固體製劑的製備中可抑制壓片期間的微粒的破裂,所述口腔崩解固體製劑包含藥物活性成分的釋放得到控制的微粒。
