Substituted spiro-compounds (I) and their pure stereoisomers, preferably enantiomer or diastereomer, racemates or mixture of stereoisomers, preferably enantiomer and/or diastereomer, salts and solvates, are new. Substituted spiro-compounds of formula (I) and their pure stereoisomers, preferably enantiomer or diastereomer, racemates or mixture of stereoisomers, preferably enantiomer and/or diastereomer, salts and solvates, are new. m : 0-4 n : 0-2 R 1>e.g. aliphatic compound, cycloaliphatic group or (hetero)aryl (all optionally substitued) either R 2>e.g. aliphatic compound, cycloaliphatic group or (hetero)aryl (all optionally substitued) and R 3>e.g. H or optionally substituted aliphatic compound or NR 2>R 3>e.g. optionally substituted cycloaliphatic group R 4>e.g. halo, NO 2 or CN R 5>e.g. H, halo, NO 2, CN or amino R 6>, R 8>e.g. optionally substituted (cyclo)aliphatic compound R 7>, R 9>e.g. H, optionally substituted aliphatic compound or optionally substituted cycloaliphatic group and R 10>-R 25>e.g. aliphatic compound, cycloaliphatic group or (hetero)aryl (all optionally substitued). Full Definitions are given in the DEFINITIONS (Full Definitions) Field. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Analgesic Antimigraine Antidepressant Neuroprotective Nootropic Antiparkinsonian Anticonvulsant Respiratory-Gen. Antiasthmatic Antiinflammatory Antitussive Uropathic Gastrointestinal-Gen. Cerebroprotective Vasotropic Dermatological Antidiarrheic Antipruritic Eating-Disorders-Gen. Immunomodulator Anabolic Anorectic Antiaddictive Cardiovascular-Gen. Muscular-Gen. Tranquilizer Hypotensive. MECHANISM OF ACTION : Vanilloid receptor-1 agonist.
