Substituted spiro-compounds (I) and their pure stereoisomers, preferably enantiomer or diastereomer, racemates or mixture of stereoisomers, preferably enantiomer and/or diastereomer, salts and solvates, are new. Substituted spiro-compounds of formula (I) and their pure stereoisomers, preferably enantiomer or diastereomer, racemates or mixture of stereoisomers, preferably enantiomer and/or diastereomer, salts and solvates, are new. m : 0-4； n : 0-2； R 1>；e.g. aliphatic compound, cycloaliphatic group or (hetero)aryl (all optionally substitued)； either R 2>；e.g. aliphatic compound, cycloaliphatic group or (hetero)aryl (all optionally substitued)； and R 3>；e.g. H or optionally substituted aliphatic compound； or NR 2>；R 3>；e.g. optionally substituted cycloaliphatic group； R 4>；e.g. halo, NO 2 or CN； R 5>；e.g. H, halo, NO 2, CN or amino； R 6>；, R 8>；e.g. optionally substituted (cyclo)aliphatic compound； R 7>；, R 9>；e.g. H, optionally substituted aliphatic compound or optionally substituted cycloaliphatic group； and R 10>；-R 25>；e.g. aliphatic compound, cycloaliphatic group or (hetero)aryl (all optionally substitued). Full Definitions are given in the DEFINITIONS (Full Definitions) Field. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Analgesic； Antimigraine； Antidepressant； Neuroprotective； Nootropic； Antiparkinsonian； Anticonvulsant； Respiratory-Gen.； Antiasthmatic； Antiinflammatory； Antitussive； Uropathic； Gastrointestinal-Gen.； Cerebroprotective； Vasotropic； Dermatological； Antidiarrheic； Antipruritic； Eating-Disorders-Gen.； Immunomodulator； Anabolic； Anorectic； Antiaddictive； Cardiovascular-Gen.； Muscular-Gen.； Tranquilizer； Hypotensive. MECHANISM OF ACTION : Vanilloid receptor-1 agonist.
