#$%^&*AU2012203243A120120621.pdf#####ABSTRACT The present invention provides a method for producing a transgenic (Tg) non-human animal capable of developing an enhanced humoral immune response against an antigen as compared to 5 a non-transgenic control animal of the same species, comprising introducing into said non-human animal a genetic construct providing for enhanced MHC class I-related neonatal Fc receptor (FcRn) activity. Also provided a Tg non-human animal comprising a genetic construct providing for enhanced FcRn activity, as well as the use of such animal in a non- therapeutical method. Therapeutic genetic constructs and methods are also provided. The present invention further 10 provides methods for producing immunoglobulins.i ! i i ! i i . I i i i i i I i i i i W0 120W Ien 2488 30 3&0G 42000 4W 54M Sess 84486 68216 48M86 s 7 sal 6M S 32 88 8288 12888 07385 RELATIVE POSITION (Base Pairs) centromer - - -1-1- . LOCSmes FCGRT LOCS22073 LOC51034 LOC51235 telomer B. I I11 IV MM 1 2 3 4 5 6 7 8 Fig. I Fig. 2 1/10
