MONTANA, JOHN GARY,FINCH, HARRY,HYND, GEORGE,CRAMP, MICHAEL COLIN,ARIENZO, ROSA,MCLEAN, NEVILLE
申请号：
CA2680682
公开号：
CA2680682C
申请日:
2008.04.03
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, for example, asthma and COPD wherein: R1 is halogen or cyano； R2 is hydrogen or methyl； R3 and R4 are independently -OR6, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen atoms； R5 is hydrogen or halogen； R6 is C1C6alkyl or C3-C6cycloalkyl, either of which being optionally substituted by one or more halogen atoms； X is -CH2-, -S-, or -O-； one of Y and Y1 is hydrogen and the other is OR6, -C(=O)R7, NR8SO2R6 or a heterocyclic group selected from those referred to in the specification； and R6, R7 and R8 are as defined in the specification.
