The present invention relates to (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of FormulaIwherein R1, R2, R3, R4, R5and R6are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.本發明係關於式I之(3－胺基－1,2,3,4－四氫－9H－咔唑－9－基)－乙酸衍生物其中R1、R2、R3、R4、R5及R6係如說明書中所述；及其作為前列腺素受體調節劑(最具體而言，作為前列腺素D2受體調節劑)在治療各種前列腺素介導之疾病及病症中的用途；含有此等化合物之醫藥組合物及用於製備該等化合物之方法。
