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APPLICATION OF AN AGENT Possessing Modifying Properties Regarding Adrenal Hormones
专利权人:
НОВАРТИС АГ (CH)
发明人:
СЮЙ Циин (US),КСАНДЕР Гэри (US),МЕРЕДИТ Эрик (US),МОНОВИЧ Лорен Г. (US),ПАПИЙОН Жюльен (US),ШУМАХЕР Кристоф (CH)
申请号:
RU2012134510/04
公开号:
RU2012134510A
申请日:
2011.01.13
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating a disease or disorder characterized by elevated levels of stress hormones and / or decreased levels of androgenic hormones in a patient, comprising administering to the patient a therapeutically effective amount of a compound of formula (I): in which n is 1 or 3; R is hydrogen or —C ( O) N (R) (R), where R and R are independently - (C — C) alkyl or - (C — C) alkyl (C — C) aryl, with each of R and R being optionally substituted with - (C — C ) alkoxy; R, R and R are independently hydrogen, halogen, cyano or - (C — C) aryl wherein said - (C — C) aryl may optionally be substituted with halogen, provided that no more than one of R, R and R is hydrogen; and R and R are hydrogen; or a pharmaceutically acceptable salt thereof. 2. The method of claim 1, wherein the compound is 4 - [(5R) -6,7-dihydro-5H-pyrrolo [1,2-c] imidazol-5-yl] -3-fluorobenzonitrile of the formula 3. The method of claim 1, wherein the compound is 4 - [(5R) -6,7-dihydro-5H-pyrrolo [1,2-c] imidazol-5-yl] -3-fluorobenzonitrile dihydrogen phosphate. A method according to any one of claims 1 to 3, wherein the disease or disorder is heart failure, cachexia, acute coronary syndrome, chronic stress syndrome, Cushing's syndrome, Cushing's disease, metabolic syndrome or hypercortisolemia. The method according to claim 4, wherein the disease or disorder is selected from acute heart failure, acute decompensated heart failure, chronic heart failure, chronic heart failure with reduced exercise tolerance, chronic heart failure with muscle weakness, cardiac cachexia, cachexia caused by CO1. Способ лечения заболевания или расстройства, характеризующегося повышенными уровнями гормонов стресса и/или пониженными уровнями андрогенных гормонов у пациента, включающий введение пациенту терапевтически эффективного количества соединения формулы (I):в которойn равно 1 или 3;R представляет собой водород или -C(O)N(R)(R), где Rи Rнезависимо представляют собой -(С-С)алкил или -(С-С)алкил(С-С)арил, причем каж
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