An apparatus, system, and method are disclosed for isolating and venting alitter box (508). The apparatus includesan enclosure (106) for a litter box, an access door (118) and a pet door inthe enclosure (106), a vent (108) between an interior andan exterior of the enclosure (106), and an exit duct (512) between theinterior and the exterior of the enclosure (106). The systemincludes a pet enclosure (106) having an enclosure door (106), a pet door(508), at least one vent (108), and at least one exhaustduct (512), a litter box (508) adapted for placement in the enclosure (106), amotor and fan (104) in fluid communication with theexit duct (512), and a conduit (102) from the exit duct. The method includesenclosing a litter box (508) in a pet container (106),drawing outside air through at least one vent (108) in the pet container (106)into an interior of the pet container (106) and exhaustingair from the pet container (106) out through an exit duct (512).