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CYCLOTIDES AS IMMUNO DEPRESSANTS
专利权人:
УНИВЕРЗИТЕТСКЛИНИКУМ ФРАЙБУРГ (DE);МЕДИЦИНИШЕ УНИВЕРЗИТЕТ ВИЕН (AT)
发明人:
ГРУБЕР Кристиан Вернер (AT),ГРЮНДЕМАНН Карстен (DE)
申请号:
RU2014129918
公开号:
RU2014129918A
申请日:
2012.12.21
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A pharmaceutical composition containing no transplanted fragments of a cyclotide, wherein said cyclotide is a head-to-tail cyclized peptide whose cyclotide chain includes six conserved cysteine residues that can form three disulfide bridges that form the motif of the cyclic cysteine site ( CCK), intended for use for immunosuppression. 2. The pharmaceutical composition of claim 1, wherein said cyclotide does not include another therapeutic peptide. The pharmaceutical composition according to claim 1 or claim 2, wherein said cyclotide contains an amino acid fragment (Formula II). XXX-Leu-Pro-Val-Cys-Gly-Glu-Xxx-Cys-Xxx-Gly-Gly-Thr-Cys -Asn-Thr-Pro-Xxx-Cys-Xxx-Cys-Xxx-Trp-Pro-Xxx-Cys-Thr-Arg-Xxx, (SEQ ID NO: 17), in which xxx denotes any amino acid not found in vivo amino acid or peptidomimetic; Xxx denotes any amino acid that is not a naturally occurring amino acid or peptidomimetic, but not Lys, and / or Xxx denotes any amino acid that is not a naturally occurring amino acid or peptidomimetic, but not Ala or Lys. 4. The pharmaceutical composition according to claim 1 or claim 2, wherein said cyclotide contains an amino acid sequence having the ability to form a cyclic framework, wherein said cyclic framework contains a structure (formula I): cyclo (C [X ... X] C [X ... X] C [X ... X] C [X ... X] C [X ... X] C [X ... X]), in which (I) C stands for cysteine; (II) [X ... X], [X ... X], [X ... X], [X ... X], [X ... X] and [X ... X] each denotes one or more amino acid residues, where each one or more amino acid residues within or between residues of the sequence can T (ym) to be equal (s) or different (i); and (III) a, b, c, d, e and f denote the number of amino acid residues in ka1. Фармацевтическая композиция, содержащая не имеющий трансплантированных фрагментов циклотид, где указанный циклотид представляет собой циклизованный по типу «голова-к хвосту» пептид, циклотидная цепь которого включает шесть консервативных остатков цистеина, которые могут формировать три дис
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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