This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to polyglutamate amino acid conjugates that can include a linker to a compound that can include a drug, and their use for a variety of drug delivery applications, e.g., anticancer.本申請案大致上是關於一種具有側位官能基的生物可相容的水溶性聚合物及其製造方法,且特別是一種聚麩胺酸鹽胺基酸複合體及將其用於多種藥物輸送應用(例如:抗癌)的用途,其中聚麩胺酸鹽胺基酸複合體可包括連接至可包括藥物之化合物的連接體。