Abdul Waseh Basit,Richard Andrew Kendall,Sudax Shina Murdan
申请号：
US10597328
公开号：
US08343545B2
申请日:
2005.01.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A method of producing microparticles having a median diameter up to 100 μm and the microparticles so produced are described. The method includes the steps of providing a solvent having a bioactive dispersed or dissolved therein and a vehicle dissolved therein, carrying out an emulsification in a non-solvent phase to produce an emulsion containing the bioactive and the vehicle in a solvent phase, and evaporating the solvent to leave the microparticles, wherein a mixture of at least two surfactants is employed to stabilize the emulsion and wherein the mixture has a hydrophilic-lipophilic balance (HLB) of up to 8.
