КАТО Ясуки (JP),ХАРАДА Мицунори (JP),ОХУТИ Михо (JP)
申请号：
RU2012137711/15
公开号：
RU2012137711A
申请日:
2011.02.07
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The composition of the polymeric micelles comprising block copolymers each of which has a hydrophobic segment and a hydrophilic polymer chain segment is a polymer chain, wherein the plurality of block copolymers are arranged radially in a state in which the hydrophobic segment of the polymer chain is directed inwards and the hydrophilic segment of the polymer chain directed outwardly, wherein the polymeric micelle composition as the block copolymer comprises a block copolymer having an affinity for HDL, and the block copolymer having an affinity for lipoprotein except a PVP block copolymer having an affinity for HDL, contains a hydrophobic segment of the polymer chain formed from the polyamic acid consisting of repeating units derived from a hydrophobic amino acid derivative, wherein the hydrophobic amino acid derivative comprises a derivative obtained by introducing in the amino acid side chain of an aromatic group and / or a sterol residue block copolymer having an affinity to lipoproteins except HDL contains a hydrophobic segment of the polymer chain formed of poly- minokisloty consisting of repeating units derived from a hydrophobic amino acid derivative, wherein the hydrophobic amino acid derivative comprises a derivative obtained by introducing a hydrophobic amino acid side chain group having a linear or branched structure iotdelenie block copolymer having an affinity for HDL, HDL induced adhesion associated with affinity, and the gap resulting from the separation promotion causes release as encapsulated dosage1. Композиция полимерной мицеллы, содержащая блок-сополимеры, каждый из которых имеет гидрофобный сегмент полимерной цепи и гидрофильный сегмент полимерной цепи, при этом множество блок-сополимеров компонуются радиально в состоянии, в котором гидрофобный сегмент полимерной цепи направлен внутрь, а гидрофильный сегмент полимерной цепи направлен наружу,где композиция полимерной мицеллы в качестве блок-сополимеров содержит блок-сополимер, обладающий срод
