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TANDEM ANTIBODIES
专利权人:
ATGC INC.
发明人:
XIAOFENG XIA
申请号:
US16291958
公开号:
US20190270828A1
申请日:
2019.03.04
申请国别(地区):
US
年份:
2019
代理人:
摘要:
This document provides methods and materials related to self-masking tandem antibodies, for example, Self-Masking Anti-tumoR Tandem antibody (SMART-body). For instance, a self-masking tandem antibody may contain two antibody-based domains (each of which contains an antigen-binding site) that are connected by a linker peptide cleavable by a protease, and the connection between the two antibody-based domains results in the masking of at least one of the antigen-binding sites. In some embodiments, for example, the SMART-body is first provided as a single molecule which does not bind antigens because of the masking of the antigen-binding sites within the molecule, but subsequently, the linker peptide is cleaved by a protease expressed in a tumor microenvironment, severing the connection between and removing the masking of the two antibody-based domains, which can then bind antigens expressed in the tumor, achieving localized, targeted cancer therapy.
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