WERNER ENGLBERGER,HANS SCHICK,BIRGITTA HENKEL,KLAUS LINZ,HELMUT SONNENSCHEIN,BERND SUNDERMANN, DR.,OTTO AULENBACHER,STEFAN OBERBOERSCH,BABETTE-YVONNE KOEGEL,CLAUDIA HINZE,ELMAR FRIEDERICHS,VALERIE SAR
申请号：
PT08022243
公开号：
PT2062898E
申请日:
2003.11.05
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
Spiro-((4-amino-cyclohexane)-1,1'-1',3',4',9'-tetrahydropyrano-(3,4-b)-indole) derivatives (I) are new. Spiro-cyclic cyclohexylamine derivatives of formula (I), optionally in the form of racemates, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions, including free bases, free acids, salts (specifically acid or base addition salt) or solvates (specifically hydrates), are new. R1, R2 = H, optionally unsaturated, optionally mono- or polysubstituted 1-4C alkyl or CHO； R3 = -(CH2)n-Aryl； n = 0-2； R4 = H, optionally unsaturated, optionally mono- or polysubstituted 1-3C alkyl or -CO-(CH2)m-H； m = 0-2； R5 - R8 = H； 1-5C alkyl or 1-3C alkoxy (both optionally unsaturated and optionally mono- or polysubstituted)； or halo, OH, SH, SMe, OMe, NH2, COOH, COOMe, NHMe, NMe2 or NO2.
