A method for controlling vascularization in a patient's eye or skin includes administering to the patient's eye or skin a pharmaceutical composition havingor a pharmaceutically acceptable salt, hydrate, enantiomer, diastereomer, racemate or mixtures of stereoisomers thereof, wherein the patient has a disease or disorder associated with vascularization in the eye or skin or wherein said patient is at risk for developing a disease or disorder associated with vascularization of the eye or skin.