The instant invention provides methods and compositions related to discovery of c-fos as a therapeutic target for treatment or prevention of neuronal diseases or disorders that are characterized by angiogenesis, or of vascular diseases of the eye and/or retinal degeneration. Therapeutic and/or prophylactic uses and compositions of c-fos inhibitors, including small molecules and nucleic acid agents, are described. Methods for identification of novel c-fos inhibitors are also provided.
