COMBINAISONS PHARMACEUTIQUES D'INHIBITEURS D'EGFR ET LEURS METHODES D'UTILISATION

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专利权人:

DANA-FARBER CANCER INSTITUTE; INC.

发明人:

GRAY, NATHANAEL S.,DE CLERCQ, DRIES,JANG, JAEBONG,JANNE, PASI,TO, CIRIC,ECK, MICHAEL,PARK, EUNYOUNG,HEPPNER, DAVID

申请号：

CA3087800

公开号：

CA3087800A1

申请日:

2019.02.20

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The application relates to a pharmaceutical combination of an allosteric EGFR inhibitor of Formula Ia or Ib: (Ia) or (Ib), or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and an ATP-competitive EGFR inhibitor of Formula I': (I'), or a pharmaceutically acceptable salt, hydrate, or solvate thereof, which modulates the activity of EGFR, a pharmaceutical composition comprising the combination, and a method of treating or preventing a disease in which EGFR plays a role.

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