Pharmaceutical combinations of EGFR inhibitors and methods of use thereof

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专利权人:

Inc.;Dana-Farber Cancer Institute

发明人:

GRAY, Nathanael S.,DE CLERCQ, Dries,JANG, Jaebong,JANNE, Pasi,TO, Ciric,ECK, Michael,PARK, Eunyoung,HEPPNER, David

申请号：

AU2019225799

公开号：

AU2019225799A1

申请日:

2019.02.20

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The application relates to a pharmaceutical combination of an allosteric EGFR inhibitor of Formula Ia or Ib: (Ia) or (Ib), or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and an ATP-competitive EGFR inhibitor of Formula I': (I'), or a pharmaceutically acceptable salt, hydrate, or solvate thereof, which modulates the activity of EGFR, a pharmaceutical composition comprising the combination, and a method of treating or preventing a disease in which EGFR plays a role.

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