Methods and compositions for cns delivery of arylsulfatase a

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专利权人:

SHIRE HUMAN GENETIC THERAPIES INC

发明人:

SHAHROKH ZAHRA,PAN JING,CHARNAS LAWRENCE,WRIGHT TERESA LEAH,SALAMAT-MILLER NAZILA,TAYLOR KATHERINE,CAMPOLIETO PAUL,CALIAS PERICLES

申请号：

NZ70279911

公开号：

NZ702799A

申请日:

2011.06.25

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Disclosed is the use of an arylsulfatase A (ASA) protein in the manufacture of a formulation for the treatment of metachromatic leukodystrophy (MLD), wherein treatment includes intrathecal administration of the formulation to a subject in need of treatment, wherein the formulation comprises an arylsulfatase A (ASA) protein at a concentration at or greater than about 5 mg/ml, and wherein the formulation comprises no greater than 50 mM of phosphate, and a polysorbate.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/