Methods and compositions for cns delivery of arylsulfatase a

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专利权人:

发明人:

SALAMAT MILLER NAZILA,TAYLOR KATHERINE,CAMPOLIETO PAUL,SHAHROKH ZAHRA,PAN JING,CHARNAS LAWRENCE,WRIGHT TERESA LEAH,CALIAS PERICLES

申请号：

IN11327/DELNP/2012

公开号：

IN2012DN11327A

申请日:

2012.12.28

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

The present invention provides among other things compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein salt and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.

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