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Quinazolindione derivatives, their preparation and therapeutic applications
专利权人:
SANOFI
发明人:
CLAUSS, Annie,GLAESS, Christophe,MARCINIAK, Gilbert,MUZET, Nicolas,NAVE, Jean-François,SEYER, André,VIVET, Bertrand
申请号:
ES08862034
公开号:
ES2567567T3
申请日:
2008.10.03
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound that responds to the general formula (I): ** Formula ** in which - A represents an aryl group or a heteroaryl group; - R1 represents: - a hydrogen atom, - -C (O) R in which R is a hydrogen atom, a (C1-C6) alkoxy group, an aryl group, a (C3-C6) cycloalkyl group, or a (C1-C6) alkyl group, said alkyl being optionally substituted with: * one or more hydroxy groups, * a benzyloxy group, * a (C1-C6) alkoxy group, optionally substituted with an aryl, or * a cycloalkyl group ( C3-C6), - a (C1-C6) alkyl group, optionally substituted; - R2 represents: - a hydrogen atom, - - a halogen atom, - a cyano group, - a nitro group, - a (C1-C6) alkyl group optionally substituted with a -NH2, or with a -NHC group (O) Rb, - a -ORa group in which Ra represents: * a hydrogen atom, * a (C1-C6) alkyl group optionally substituted with one or more halogen atoms, with one or more hydroxy groups, with a aryl group and / or with one or several cyano groups, * a (C2-C6) alkynyl group; * an aryl group; - R3 represents: - a hydrogen atom, - a halogen atom, - a hydroxy group, - a cyano group, - a -SCF3 group, - a nitro group, - an oxo group, - a -S (O) group 0-2-alkyl, a group -S (O) 0-2-heterocycloalkyl, a group -O-SO2-aryl optionally substituted with one or more halogen atoms; - a group -alkyl-amino-alkyl or -cycloalkyl-amino-alkyl, each optionally substituted in the terminal alkyl, - an optionally substituted sulfonamide group, - an aryl group or a heteroaryl group, said group being monocyclic or polycyclic and being further optionally substituted with a (C1-C8) alkyl group, with one or more halogen atoms, or with a (C1-C6) alkoxy group, - a heterocycloalkyl group optionally substituted with a (C1-C6) alkyl group, - a (C1-C6) alkyl group, optionally substituted with: - one or more halogen atoms, - an aryl group, which may be substituted with one or more halogen atoms, or with one or more hydroxy groups, - a heteroaryl group, - one or more hydroxy groups, which may be substituted with an a
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