ARORA TARUNA,PASZTY CHRISTOPHER J. R.,RICHARDS WILLIAM G.,FLORIO MONICA
申请号：
ARP120100682
公开号：
AR085600A1
申请日:
2012.03.02
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
Claim 1: a Molecule of Union which consists of a polypeptide Chain, where the polypeptide Chain consists of VH1 vh2 (x1) - N - (N - (x2)Where: VH1 is a First variable domain of heavy chain derived from a first portion of the parental Antibody or Antigen in Union； vh2 is a Second variable domain of heavy chain derived from a Second parental Antibody or Antigen binding portion in this C is a constant Domain； heavy chain； n (x1) is a Body of the Union,Where N (x1) that is either present as Absent (x2)； and N is an FC region (x2), where n is either present and Absent, where Union Molecule binds specifically to both the Sclerostin and dkk-1.Claim 78: a method to generate a binding Molecule that binds to Sclerostin and dkk-1, which consists of the steps: (a) obtaining a First parental Antibody or Antigen binding portion therein, which can be attached to Sclerostin or dkk-1； (b) obtaining a sec Undo parental Antibody or Antigen binding portion therein,That can be attached to Sclerostin or dkk-1； (c) the Construction of the first and Third polypeptide Chains which consist of VH1 vh2 (x1) - N - (N - (x2)Where: VH1 is a First variable domain of heavy chain obtained from these First parental Antibody or Antigen binding portion therein； vh2 is a Second variable domain of heavy chain obtained from Said Second parental Antibody or Antigen binding portion and N； c is a constant domain of heavy chain； n (x1) is a Body of Union with the condition that noCH1 is said (x1), where n is either present or absent； and (x2) is a FC region (x2), where n is either present or absent； (d) the Construction of the second and Fourth polypeptide Chains which consist of VL1 (x1) - N - VL2 C - N - (x2),Where: VL1 is a first light chain variable Domain obtained from Said First parental Antibody or Antigen binding portion is in a Second VL2； light chain variable Domain obtained from Said Second parental Antibody or Antigen binding of Body C is a constant Domain； light chain； n (x1) is a Body of the Uni
