THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;THE CHILDREN'S HOSPITAL OF PHILADELPHIA
发明人:
JUNE, CARL, H.,LEVINE, BRUCE, L.,KALOS, MICHAEL D.,GRUPP, STEPHAN
申请号：
EP13817210
公开号：
EP2872171A4
申请日:
2013.07.12
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need thereof a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain and monitoring the levels of cytokines in the patient post T cell infusion to determine the type of second-line of therapy appropriate for treating the patient as a consequence of the presence of the CAR T cell in the patient.
