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METHOD OF PREPARING STILBENE-LOADED POLYMERIC PARTICLES, OBTAINED PARTICLES AND THEIR USE
专利权人:
Macau University of Science and Technology
发明人:
JIN, Hua,CAI, Jiye,WU, Chaomin,PI, Jiang,JIANG, Jinhua
申请号:
AU2016100089
公开号:
AU2016100089A4
申请日:
2016.02.01
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2016100089A420160310.pdf#####ABSTRACT The present invention refers to a method for preparing stilbene-loaded polymeric particles comprising the preparation of an emulsion with the stilbene and a subsequent hardening of the polymeric particles, wherein the polymeric particles comprise poly(lactic-co-glycolic acid) and certain modifying polymer. The method for preparing stilbene-loaded polymeric particles of the present invention is highly advantageous allowing for the preparation of stilbene-loaded polymeric particles with a high yield and an exceptionally high loading and encapsulation rate. The prepared particles provide advantageous water solubility and exceptional biocompatibility, allowing for a significantly increased bioactivity of the stilbene. The invention, thus, provides a highly attractive delivery system for stilbenes. The present invention further refers to the obtained stilbene-loaded polymeric particles as well as a pharmaceutical composition comprising them. In a further aspect, a method of treating a subject suffering from an inflammatory disease or cancer is provided. 32/ t ,,~.~ 1 / .4 V4 4 14) A Ii 4~ V. N S 4 S n... r 4 ~ t V Jr LJ~ ".4 4 ~ 4 445 / Kr N I /
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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