INC.;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;CHILDREN'S MEDICAL CENTER CORPORATION;THE BRIGHAM AND WOMENS HOSPITAL
发明人:
FRANK, MARKUS, H.,FRANK, NATASHA, Y.
申请号：
EP09826430
公开号：
EP2356446A4
申请日:
2009.11.13
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
Genes that are deregulated in cancer stem cells (e.g., melanoma stem cells) are disclosed. Methods which involve modulating (e.g., inducing, inhibiting, etc.) the activity of the cancer stem cell associated genes are used to treat individuals having melanoma. Cell surface genes that are upregulated in melanoma stem cells are targeted for the selective isolation, detection, and killing of cancer stem cells in melanoma.
