Mutant OPAA enzymes with increased catalytic efficiency on cyclosarin

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专利权人:

U.S. Army Edgewood Chemical Biological Center

发明人:

Steven P Harvey,Melissa M Dixon,Mark A Guelta

申请号：

US15875071

公开号：

US10538749B1

申请日:

2018.01.19

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The invention comprises isolated, mutant, non-wild-type organophosphorus acid anhydrolase (OPAA) enzymes having two site mutations, methods of production, and methods of use to effectively degrade cylcosarin (GF) (cyclohexyl methylphosphonofluoridate) with greater catalytic efficiency than the wild-type OPAA.

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