PROBLEM TO BE SOLVED: To provide a composition having a basement membrane protective action by suppressing the production of CXCR4. SOLUTION: A composition for suppressing the production of CXCR4 containing prunetin and / or a plant extract containing prunetin as an active ingredient. [Selection diagram] Fig. 1【課題】CXCR4の産生を抑制し、基底膜保護作用を有する組成物を提供すること。【解決手段】プルネチン及び/又はプルネチン含有植物抽出物を有効成分として含有するCXCR4産生抑制用組成物。【選択図】図1