Wang, Longgui,Liu, Xiaomei,Mo, Lian,Mencher, Simon,Mccarron, James
申请号：
ES11157590
公开号：
ES2559183T3
申请日:
2005.01.06
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A pharmaceutical composition for use in the treatment of an inflammatory disease associated with cytokine expression levels, comprising at least one compound of formula (I) or formula (II) ** Formula ** in which R3, R4 , R5, R6, R7, R8, R9 and R10 are the same or different and represent a hydrogen atom； a hydroxy group； a nitrous group； a nitro group； a monosaccharide； a disaccharide； a halogen atom； a hydrocarbyl group or a functional hydrocarbyl group unsubstituted or substituted with one or more hydroxy moieties, carboxy moieties, nitroxy moieties, monosaccharides, disaccharides, amines, amides, thiols, sulfates, sulfonates, sulfonamides or halogens, in which the hydrocarbyl has 1 at 8 carbon atoms； a group -R11R12, in which R11 and R12 may be the same or different and represent a hydrogen atom, a straight chain or branched chain alkyl group having 1 to 18 carbon atoms which may additionally carry one or more hydroxy and / or amino groups, a substituted or unsubstituted aryl group that may comprise one or more heteroatoms or an acyl group, or R11 and R12 together form a ring having 2 to 6 optionally substituted CH2 groups； an azo group -N>； = N-R13, in which R13 represents an aromatic system that may be substituted with one or more carboxyl groups and / or phosphoryl groups or a group selected from the group consisting of sugars, amino acids, peptides or hormones steroids； or R1 and R6, and R2 and R7, respectively, independently form each other, a ring together having 1 to 4 optionally substituted CH2 groups； and R1 and R2 are the same or different and represent a hydrogen atom； a halogen atom； a hydroxy group； a hydrocarbyl group or a functional hydrocarbyl group unsubstituted or substituted with one or more hydroxy moieties, carboxy moieties, nitroxy moieties, monosaccharides, disaccharides, amines, amides, thioles sulfates, sulfonates, sulfonamides or halogens, in which the hydrocarbyl has 1 to 8 carbon atoms； a mono-, di- or trialkylsilyl group having 1 to
