In a medicine packaging apparatus, a distance from a printing section to a heat sealing section is reduced without generating wrinkles on a package sheet. An unfolding guide 65 for unfolding and opening a package sheet 61 provided in a packaging unit 4 includes a main ridge 94 extending along with a crease of the package sheet 61 and a pair of unfolding guide surfaces 95a, 95b which are convex curved surfaces stretching from the main ridge 94. A contact start position 100a with the package sheet 61 of the unfolding guide surface 95a on the outer side of a curve in the conveying direction A relative to the main ridge 94 is located on an upstream side in the conveying direction A of the package sheet 61 of a contact start position 100b with the package sheet 61 of the unfolding guide surface 95b located on the inner side of the curve relative to the main ridge 94.
