ANTICORPS ANTI-TENB2 MODIFIÉS PAR DES CYSTÉINES ET CONJUGUÉS ANTICORPS-MÉDICAMENT

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专利权人:

GENENTECH; INC.

发明人:

申请号：

EP08839947.2

公开号：

EP2209808B1

申请日:

2008.10.16

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p&emsp；&emsp；I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.

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