1,4 oxazines as inhibitors of bace1 and / or bace2

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专利权人:

F. HOFFMANN-LA ROCHE AG;SIENA BIOTECH S.P.A.

发明人:

EMANUELE GABELLIERI,MASSIMILIANO TRAVAGLI,MATTEO ANDREINI,ROBERT NARQUIZIAN,WOLFGANG WOSTL

申请号：

BR112013014610

公开号：

BR112013014610A2

申请日:

2012.01.31

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

The present invention provides 1,4 Oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

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