Crystalline fumarate Salt of (S) - 3,4 - difluoro - [2 - (4 - fluoro - yodofenilamino) phenyl] [3 - hydroxy - 3 - (2 - azetidin piperidin yl) - triazin-1-yl] - methanone

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专利权人:

EXELIXIS; INC.

发明人:

BROWN, Adrian St. Clair

申请号：

PE0028692017

公开号：

PE6922018A1

申请日:

2016.06.30

申请国别(地区):

PE

年份:

2018

代理人:

摘要：

This referred to the Crystalline fumarate Salt of (S) - 3,4 - difluoro - [2 - (4 - fluoro - yodofenilamino) phenyl] [3 - hydroxy - 3 - (2 - azetidin piperidin yl) - triazin-1-yl] - methanone In addition,The pharmaceutical compositions comprising the Salt thereof.It also relates to the use of this salt in Methods to treat cancers such as melanoma, colorectal cancer, Lung Cancer, among othersEsta referido a la sal de fumarato cristalina de (S)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil] [3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona ademas, a sus composiciones farmaceuticas que comprende la sal del mismo. Tambien se refiere al uso de esta sal en metodos para tratar canceres como melanoma, cancer colorrectal, cancer de pulmon, entre otras

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