1--3- -1 31 40 Novel 1-Benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1 CX3CR1 and P40
The present invention relates to novel 1-benzyl-3-hydroxymethylindazoles derivatives according to formula (I) as described in the claims, and pharmaceutical compositions comprising them together with pharmaceutical excipients. The present invention also relates to the use of 1-benzyl-3-hydroxymethyl indazole derivatives for the preparation of a pharmaceutical composition effective for the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40 and to the use of MCP-1, CX3CR1 And methods of treating or preventing diseases based on the expression of p40.본 발명은 청구항들에 기술된 화학식(I)에 따른 신규한 1-벤질-3-하이드록시메틸인다졸 유도체들 및 이들과 함께 약학적 부형제를 포함하는 약학적 조성물에 관한 것이다. 또한, 본 발명은 MCP-1, CX3CR1 및 p40의 발현을 기초로 한 질환들을 치료에 효과적인 약학적 조성물의 제조를 위한 1-벤질-3-하이드록시메틸인다졸 유도체들의 용도 및 MCP-1, CX3CR1 및 p40의 발현을 기초로 한 질환들을 치료하거나 예방하기 위한 방법에서 이의 용도에 관한 것이다.
