SHU LEI,CHEUNG ATWOOD,CHIN DONOVAN NOEL,DALES NATALIE,FAZAL ALEEM,HURLEY TIMOTHY BRIAN,KERRIGAN JOHN,O&rsquo,BRIEN GARY,SUN ROBERT,SUNG MOO,O&rsquoBRIEN GARY
申请号：
NZ70473813
公开号：
NZ704738A
申请日:
2013.08.13
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a compound or salt thereof according to Formula (I) A is 2-hydroxy-phenyl which is substituted with 0, 1, 2, or 3 substituents independently selected from C1-C4alkyl, wherein 2 C1-C4alkyl groups can combine with the atoms to which they are bound to form a 5-6 membered ring and is substituted with 0 or 1 substituents selected from oxo, oxime and hydroxy,haloC1-C4alkyl, dihaloC1-C4alkyl, trihaloC1-C4alkyl, C1-C4alkoxy, C1-C4alkoxy- C3-C7cycloalkyl, haloC1-C4alkoxy, dihaloC1-C4alkoxy, trihaloC1-C4alkoxy, hydroxy, cyano, halogen, amino, mono- and di-C1-C4alkylamino, heteroaryl, C1-C4alkyl substituted with hydroxy, C1-C4alkoxy substituted with aryl, amino, -C(O)NH C1-C4alkyl &ndash； heteroaryl, -NHC(O)- C1-C4alkyl- heteroaryl, C1-C4alkyl C(O)NH- heteroaryl, C1-C4alkyl NHC(O)- heteroaryl, 3-7 membered cycloalkyl, 5-7 membered cycloalkenyl or 5, 6 or 9 membered heterocycle containing 1or 2 heteroatoms, independently, selected from S, O and N, wherein heteroaryl has 5, 6 or 9 ring atoms, 1, 2 or 3 ring heteroatoms selected from N, O and S and substituted with 0, 1, or 2 substituents independently selected from oxo, hydroxy, nitro, halogen, C1-C4alkyl, C1-C4alkenyl, C1-C4alkoxy, C3-C7cycloalkyl, C1-C4alkyl-OH, trihaloC1-C4alkyl, mono- and di-C1-C4alkylamino, -C(O)NH2, -NH2, -NO2, hydroxyC1-C4alkylamino, hydroxyC1-C4alkyl, 4-7member heterocycleC1-C4alkyl, aminoC1-C4alkyl and mono- and di-C1-C4alkylaminoC1-C4alkyl； or wherein B is selected from a group consisting of nitrogen containing heterocycles； wherein Z is O or N(Me)； and R17 is hydrogen or methyl. Also disclosed is the compound5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol, or salt thereof. Also disclosed is the compound 2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)phenol, or salt thereof.
