Provided herein are smart functional fabrics and therapeutic/diagnostic garments which utilize flexible wireless electronic devices to enhance functionality, for example, by measuring key therapy parameters and providing data to clinicians, and methods utilizing such devices. The provided methods are designed to avoid patient discomfort and decrease harm or irritation caused by garments which utilize bulkier, more rigid sensors. Additionally, the described devices are multiplexed to allow for sensing of multiple parameters of therapeutic interest and combinations of measured data for new clinical metrics.