GST 28 KDa proteins that come from schistosomes for use in the treatment of autoimmune inflammatory diseases that generate a Th1 and / or Th17 type response
INSERM - Institut National de la Santé et de la Recherche Médicale;Centre National de la Recherche Scientifique;Centre Hospitalier Regional Universitaire de Lille;Université de Lille
Product chosen from a protein, a fragment of said protein, a derived sequence and a homologous sequence of said protein, characterized in that: - said protein comprises or is constituted by the 28 KDa Glutathione S-transferase protein of a schistosome chosen from Schistosoma haematobium, Schistosoma mansoni, Schistosoma bovis respectively represented by the sequences SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3； - said fragment is a fragment of one of said proteins comprising, at least one region comprised between the following regions: the region comprised by the amino acid from position 15 to the amino acid at position 60, the region comprised by the amino acid from the position 20 to the amino acid at position 50, the region comprised by the amino acid from position 24 to the amino acid at position 43, the region comprised by the amino acid from position 170 to the amino acid at position 220, the region comprised by the amino acid of the position 180 to the amino acid at position 215, the region comprised by the amino acid from position 190 to the amino acid at position 211 of the sequence SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3； this generating a Th2 type immune response, characterized by the production of IL-4, IL-5 or IL-13 by lymphocytes that do not produce gamma IFN； and this decreasing the Th1 type immune response, the Th1 type immune response being characterized by the production of gamma IFN and TNF by lymphocytes that do not produce IL-4 or IL-5, and the production of IL-1b by tissues rat colon； - said derived sequence is obtained from one of said sequences SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3 or one of said fragments mentioned above and is obtained in particular by deletion, substitution or addition of one or more amino acids, in the sequence SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, said derived sequence comprising at least one region comprised between the following regions: the region comprised by the amino acid of position 15 to the amino
