Alfred Williams;Matthew R. Redinbo;Kimberly Terry Lane;John Scott;Sridhar Mani;Bret David Wallace;Li-An Yeh
发明人:
Matthew R. Redinbo,Sridhar Mani,Alfred Williams,John Scott,Li-An Yeh,Bret David Wallace,Kimberly Terry Lane
申请号：
US13514418
公开号：
US08557808B2
申请日:
2010.12.09
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Compounds, compositions and methods are provided that comprise selective β-glucuronidase inhibitors for both aerobic and anaerobic bacteria, especially enteric bacteria normally associated with the gastrointestinal tract. The compounds, compositions and methods can be for inhibiting bacterial β-glucuronidases and for improving efficacy of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds by attenuating the side effects caused by reactivation by bacterial β-glucuronidases of glucuronidated metabolites of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds.
