the way to obtain \u043f\u043e\u043b\u0438\u043c\u043e\u0440\u0444\u043d\u043e and chemically stable solid oral drug \u0431\u0430\u0437\u0435\u0434\u043e\u043a\u0441\u0438\u0444\u0435\u043d\u0430 acetate, containing antioxidants, including: (a) the wet part of the substance in the form of granules obtained by the wet granulation (b) receiving a part of the final product obtained by direct mix \u0438\u0432\u0430\u043d\u0438\u044f or dry granulation (c) mixing parts in proportionwhich varies from 25: 75 75: 25 (d) the possible \u043f\u0440\u0438\u043c\u0435\u0448\u0438\u0432\u0430\u043d\u0438\u0435 additional powdery \u044d\u043a\u0441\u0446\u0438\u043f\u0438\u0435\u043d\u0442\u043e\u0432, such as one or more than one device, one or more e than one substance to the slide, and \/ or one or more than one \u0441\u043c\u0430\u0437\u044b\u0432\u0430\u044e\u0449\u0435\u0435 substance and (e) to obtain the final product by (i) pressing the mixture with \u0435\u0440\u0434\u0446\u0435\u0432\u0438\u043d\u044b pills and coating \u0441\u0435\u0440\u0434\u0446\u0435\u0432\u0438\u043d shell\u0432\u043b\u0430\u0433\u043e\u0437\u0430\u0449\u0438\u0442\u043d\u044b\u0435 containing polymers (ii) filling the mixture in \u0432\u043b\u0430\u0433\u043e\u0437\u0430\u0449\u0438\u0442\u043d\u044b\u0435 capsules where the active connection \u0431\u0430\u0437\u0435\u0434\u043e\u043a\u0441\u0438\u0444\u0435\u043d\u0430 acetate include either in a wet part lib in a part where a part of an active connection \u0431\u0430\u0437\u0435\u0434\u043e\u043a\u0441\u0438\u0444\u0435\u043d\u0430 acetate, includes a first stage of the preliminary mixing \u0431\u0430\u0437\u0435\u0434\u043e\u043a \u0441\u0438\u0444\u0435\u043d\u0430 acetate with free filler.Водный способ получения полиморфно и химически стабильного перорального твердого препарата базедоксифена ацетата, не содержащего антиоксидантов, включающий: a) получение влажной части препарата в форме гранул, полученных путем влажной грануляции b) получени
