Emanuel Fleige,Sam Moré,Michael Unbehauen,Rainer Haag,Christoph Stein,Halina Machelska-Stein,Florian Paulus
申请号：
US15780954
公开号：
US20180344857A1
申请日:
2016.12.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.
