UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
发明人:
KIM, Sung Soo,김성수,CHO, Won Jea,조원제
申请号：
KRKR2014/008402
公开号：
WO2015/037892A1
申请日:
2014.09.05
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to: a novel bis-amide derivative compound or a pharmaceutically acceptable salt thereof a preparation method therefor and a pharmaceutical composition for preventing or treating diseases caused by hepatitis C virus infection and a dietary supplement for preventing or alleviating diseases caused by hepatitis C virus infection, containing the bis-amide derivative compound or a pharmaceutically acceptable salt thereof as an active ingredient. The novel bis-amide derivative compound of the present invention, particularly WJCPA-126, specifically binds to the catalytic site of CypA to effectively inhibit the activity of an isomerase, and the duration of the inhibitory effect can be increased since WJCPA-126 binds to CypA with a high binding force exhibiting a low dissociation rate (Koff). Accordingly, WJCPA-126 has nontoxic and non-immunosuppressive characteristics and can effectively inhibit HCV replication in vitro and in vivo model systems. In addition, WJCPA-126 reactivates the host interferon response through an increase in the expression of IFN stimulated genes (ISGs) and the inhibition of interleukin-8 (IL-8) secretion. Therefore, a series of the bis-amide derivatives including WJCPA-126 can be useful as a novel type CypA inhibitor exhibiting antiviral efficacy.La présente invention concerne un nouveau composé dérivé de bis-amide ou un sel pharmaceutiquement acceptable de ce composé un procédé pour sa préparation et une composition pharmaceutique pour la prévention ou le traitement de maladies provoquées par une infection par le virus de lhépatite C et un supplément alimentaire pour la prévention ou le soulagement de maladies provoquées par une infection par le virus de lhépatite C, contenant le composé dérivé de bis-amide ou un sel pharmaceutiquement acceptable de ce dernier en tant que principe actif. Le nouveau composé dérivé de bis-amide de la présente invention, en particulier WJCPA-126, se lie spécifiquement au site catalytique
