GLASS, DAVID J.,YANCOPOULOS, GEORGE D.,PAPADOPOULOS, NICHOLAS J.,DALY, THOMAS J.
申请号：
DK10007017
公开号：
DK2241575T3
申请日:
2006.01.06
申请国别(地区):
DK
年份:
2015
代理人:
摘要：
A fusion protein comprising at least one IGF1 variant component and a fusion component (F), and, optionally, a signal sequence, exhibiting improved stability relative to the native IGF1 or IGF2 polypeptide. The fusion component (F) may be a multimerizing component, a targeting ligand, or another active or therapeutic compound. IGF1 variants were shown to have improved ability to induce skeletal muscle hypertrophy relative to native IGF1.
