The present invention is related a ketorolac implant and preparation, wherein the ketorolac implant comprises a ketorolac and a degraded vector. The ketorolac implant is prepared by the hot melt extrusion, so the ketorolac implant is used for preventing or treating the acute or chronic pain and inflammation by releasing a drug at the preset releasing-drug time via the zero-order reaction. The ketorolac implant in the present invention sustained releases and has no the event of the immediate-release, so it has great advantage in the clinical use.本發明關於一種酮咯酸植入劑及其製備方法，其中該酮咯酸植入劑含有酮咯酸以及可降解載體，採用熱熔擠出法製備，可在預設的釋藥時間內零級動力學方式釋放藥物，可用於預防或治療急慢性疼痛和炎症。本發明製備的酮咯酸植入劑，釋放穩定，無突釋效應具有極大的臨床使用優勢。
