Urs Utzinger,Bhaskar Banerjee,Timothy E. Renkoski,Nathaniel S. Rial,Logan Graves
申请号：
US14415311
公开号：
US09952157B2
申请日:
2013.07.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods for reliable identification of low-contrast lesions within a tissue of a subject comprise delivering an excitation signal to the tissue, wherein the excitation signal is selected to stimulate tissue to produce autofluorescence and/or reflectance. The autofluorescence and/or reflectance is detected, and ratiometric images are produced based on the autofluorescence and/or reflectance images. An imaging system is provided which is configured to carry out such methods, irradiating tissue at a various possible excitation wavelengths, such as UV excitation wavelengths below 300 nm, to elicit fluorescence from specific native fluorophores.
