PROBLEM TO BE SOLVED: To provide a compound having excellent adenosine monophosphate activated protein kinase (AMPK) activation effect and useful for treatment and/or prevention of diabetes, obesity, hypercholesterolemia, hypertension or the like.SOLUTION: There is provided a compound having a 3H-imidazo[4,5-b]pyridine skeleton represented by the following formula or a pharmaceutically acceptable salt thereof. R4 is H, R1 is morpholine, thiomorpholine, substitutable pyrrolidine, substitutable piperidine, substitutable piperazine, indole, oxazole, isoxazole, substitutable phenyl, alkoxy, phenyl substituted by substituted amine or the like or the like, R2 is halogen or substituted/unsubstituted alkyl, R3 is H, halogen, hydroxy, cyano, nitro, carboxy, substituted alkyl, substituted/unsubstituted alkenyl, substituted/unsubstituted alkynyl or the like, X is a single bond, S or O and Y is substituted/unsubstituted hetero ring or the like.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】優れたアデノシン一リン酸活性化プロテインキナーゼ(AMPK)活性化作用を有し、糖尿病、肥満、高コレステロール血症、高血圧等の治療及び/又は予防に有用な化合物の提供。【解決手段】下記式で表される3H-イミダゾ[4,5-b]ピリジン骨格を有する化合物又はその製薬上許容される塩。(R4はH;R1はモルホリン、チオモルホリン、置換可ピロリジン、置換可ピペリジン、置換可ピペラジン、インドール、オキサゾール、イソキサゾール、置換可フェニル、アルコキシ、置換アミノ等で置換されたフェニル等;R2はハロゲン又は置換/非置換アルキル;R3はH、ハロゲン、ヒドロキシ、シアノ、ニトロ、カルボキシ、置換アルキル、置換/非置換アルケニル、置換/非置換アルキニル等;Xは単結合、S又はO;Yは置換/非置換ヘテロ環等)【選択図】なし
