A method and a processor for determination of Window settings of 3D medical images In a method (1000) for determination of window settings for optimal visualization of a 3D dataset, a plurality of projections (30, 50) are obtained from the 3D dataset. These projections (30, 50) have different window settings. In the method, a 2D image (10) is used. The 2D image (10) has a first edge set (15) at least containing a first edge (12), and each of the projections (30, 50) have a corresponding second edge set (35, 55) at least containing a second edge (32, 52). Subsequently, the first edge set (15) is compared with corresponding second edge sets (35, 55). Finally, the window settings of that projection (30, 50) for which the first edge set (15) optimally correlates with the second edge set (35, 55) is selected.